Results
| PMID | 18706208 |
| Gene Name | ANXA1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 41 |
| Population details | 41 (25 women with endometriosis, 16 age-matched women without endometriosis) |
| Sex | Female |
| Associated genes | Annexin-1 |
| Other associated phenotypes |
Endometriosis |
|
Chin Med J (Engl). 2008 May 20;121(10):927-31. Li, Chun-yan| Lang, Jing-he| Liu, Hai-yuan| Zhou, Hui-mei Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. BACKGROUND: Annexin-1 was identified as an endometriosis-related protein by comparative proteomics in previous study. As an endogenous anti-inflammatory mediator, Annexin-1 has been shown to regulate the immune response, cell proliferation and apoptosis. To investigate whether Annexin-1 is involved in the pathogenesis of endometriosis, we examined the expression of Annexin-1 in eutopic endometrium of women with or without endometriosis, and detected its expression in peritoneal fluids of those with endometriosis. METHODS: Eutopic endometrium samples from twenty-five women with endometriosis and those from sixteen age-matched women without endometriosis were collected. Peritoneal fluids were obtained from ten patients with endometriosis. The expression of Annexin-1 protein in eutopic endometrium was detected by immunohistochemistry and Western blotting, and mRNA detected by real-time PCR. Annexin-1 protein in the peritoneal fluids was detected by Western blotting. RESULTS: Annexin-1 mRNA and protein were overexpressed in eutopic endometrium of endometriosis without significant differences between the proliferative and secretory phase. Immunohistochemistry showed that Annexin-1 protein was expressed mainly in endometrial glandular cells throughout the menstrual cycle. Annexin-1 protein was detected in the peritoneal fluids of all the ten patients with endometriosis. CONCLUSIONS: Annexin-1 is overexpressed in eutopic endometrium and presents in the peritoneal fluids of patients with endometriosis, and may play a role in the pathogenesis of endometriosis. Mesh Terms: Adult| Annexin A1/genetics/*metabolism| Ascitic Fluid/metabolism| Blotting, Western| Endometriosis/genetics/metabolism/*pathology| Female| Gene Expression| Humans| Immunohistochemistry| Middle Aged| RNA, Messenger/genetics/metabolism| Reverse T |
|